ASI 2017* The role of TGFβ in shaping TRM identity in epithelial and non-epithelial environs (#188)
Tissue-resident memory T cells (TRM) are a distinct subset of non-recirculating cells that provide local immune protection. We have recently identified a core transcriptional signature of TRM that render these cells distinct from circulating memory T cells. Importantly, we demonstrate differential gene expression between TRM found in epithelial and non-epithelial tissues, owing to the interplay of cytokine signalling in these microenvironments. We have found that transforming growth factor β is critical for the core signature and survival of TRM in epithelial tissue, but is not required for TRM in certain non-epithelial sites. Collectively, our work underscores the adaptability of TRM to distinct tissue microenvironments, and highlights the differential profiles of TRM in various sites. These insights will direct T cell-based therapies to improve long-term immune protection.
