Defining skin-resident T cells in mouse and human — ASN Events
  1. Schedule
  2. Poster Session One & Burnet Oration Cocktail Function
  3. Defining skin-resident T cells in mouse and human

Defining skin-resident T cells in mouse and human (#178)

Clara Castellucci 1 , Jolie G Cullen 1 , Stuart P Berzins 2 3 , Francis R Carbone 1 , Daniel G Pellicci 1 , Laura K Mackay 1
  1. Department of Microbiology and Immunology, The Peter Doherty Institute, the University of Melbourne, Melbourne, Victoria, Australia
  2. Collaborative Research Network, Federation University, Ballarat, Victoria, Australia
  3. Fiona Elsey Cancer Research Institute, Ballarat, Victoria, Australia

Tissue-resident memory T cells (TRM) are a long-lived subset of CD8+ T cells that are permanently located in tissue and are at disequilibrium with the circulation. Their residency in barrier tissues, such as the skin, poises TRM for local protection in various setting such as viral infection and cancer. Most studies focus on the characterization of CD8+TRM, however, there is a gap in the understanding of CD4+ T cells and their potential to form TRM. Therefore, we aim to phenotypically and transcriptionally define CD4+ TRM in mouse skin in order to identify the comparative and distinct pathways with CD8+ TRM.  Importantly, we have also developed a technique for extracting and phenotyping TRM from healthy and diseased human skin, which allows us to compare the translational potential of mouse studies. Together, this information will provide the foundation for characterizing TRM in human skin pathologies and identify new therapeutic targets. 

 

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