Progressive multiple sclerosis (MS) is a debilitating neurological disease characterised by severe and accumulating disability without periods of remission.  Most patients with progressive MS are refractory to current disease modifying treatments.  To profile this severe form of MS, we compared peripheral blood immune cell numbers and phenotype of untreated patients with a cohort of healthy subjects.  The data showed a raised CD4:CD8 ratio, often noted in progressive MS, and our detailed phenotyping revealed minor subset alterations in this raised ratio: an increased in CD4⁺ central memory T-cells, and a concurrent decrease in naive CD8⁺ T-cells.  Furthermore, we noted a reduction in absolute numbers of CD4^-CD8^- T-cells, plasmacytoid dendritic cells, and an increase in neutrophils. In contrast, NK-cells, B-cells, monocytes and overall leukocyte counts were within normal reference ranges. Progressive MS often follows on from a relapsing remitting disease course.  We believe these detailed subset changes indicate a dysregulation in peripheral blood innate immune cell composition, and that the T-cell subset alterations noted here may be secondary to progressive pathophysiological processes.