Following his medical studies at the University of Queensland, Jonathan Sprent received his Ph.D. with Jacques Miller at the Walter and Eliza Hall Institute in Melbourne studying the thymus and T cells. After postdocs at the Basel Institute in Switzerland and the University College London, he worked for 30 years in the USA, first at the University of Pennsylvania in Philadelphia and then at the Scripps Research Institute in San Diego. In 2006 he moved to the Garvan Institute of Medical Research in Sydney. His research group is interested in various aspects of T cell biology, including thymic selection, T cell memory and homeostasis, transplantation immunity and cancer immunotherapy. He is past President of the American Association of Immunology, Fellow of the Royal Society, Fellow of the Australian Academy of Science, and Member of the National Academy of Sciences USA.